Earlier Colonial era
Nearly all commercial activity was run in small privately owned businesses with good credit both at home and in England being essential since they were often cash poor. Most settlements were nearly independent of trade with Britain as most grew or made nearly everything they needed—the average cost of imports per most households was only about 5-15 English pounds per year. Most settlements were created by complete family groups with several generations often present in each settlement. Probably close to 80% of the families owned the land they lived and farmed on. They nearly all used English Common Law as their basic code of law and, except for the Dutch and Germans, spoke some dialect of English. They established their own popularly elected governments and courts and were, within a few years, mostly self governing, self supporting and self replicating.
Nearly all colonies and, later, states in the United States were settled by migration from another colony or state, as foreign immigration usually only played a minor role after the initial settlements were started. Many new immigrants did end up on the frontiers as that was where the land was usually the cheapest.
New England
The New England colonists included more educated men as well as many skilled farmers, tradesmen and craftsmen. They were mostly farmers and settled in small villages for common religious activity. Shipbuilding, commerce, and fisheries were important in coastal towns. New England's healthy climate (the cold winters killed the mosquitoes and other disease-bearing insects), and abundant food supply resulted in the lowest death rate and highest birth rate of any place in the world (marriage was expected and birth control was not, and a much higher than average number of children and mothers survived).
The eastern and northern frontier around the initial New England settlements was mainly settled by the Yankee descendants of the original New Englanders. Emigration to the New England colonies after 1640 and the start of the English Civil War decreased to less than 1% (about equal to the death rate) in nearly all years prior to 1845. The rapid growth of the New England colonies (total population ~700,000 by 1790) was almost entirely due to the high birth rate (>3%) and low death rate (<1%) per year.
Middle Colonies
The middle colonies' settlements were scattered west of New York City, New York (est. 1626 by Dutch, taken over by the English in 1664) and Philadelphia, Pennsylvania (est. 1682). The Dutch-started colony of New York had the most eclectic collection of residents from many different nations and prospered as a major trading and commercial center after about 1700. The Pennsylvania colonial center was dominated by the Quakers for decades after they emigrated there, mainly from the North Midlands of England, from about 1680 to 1725. The main commercial center of Philadelphia was run mostly by prosperous Quakers, supplemented by many small farming and trading communities with strong German contingents located in the Delaware River valley.